In a large skillet over medium heat, brown the ground beef until fully cooked, about 5-7 minutes. Drain any excess fat.
Stir in garlic powder, onion powder, chili powder, cumin, salt, and pepper. Cook for an additional 2-3 minutes until the spices are fragrant.
Remove the skillet from heat and mix in the shredded cheddar cheese until melted and well combined.
Lay out the flour tortillas on a clean surface. Divide the beef and cheese mixture evenly among the tortillas, placing it in the center of each.
Top each with a handful of cooked French fries and a spoonful of salsa.
Fold in the sides of the tortilla, then roll it up tightly from the bottom to the top.
Place the burritos seam-side down in a greased baking dish.
Bake in a preheated oven at 350°F for 15-20 minutes until the tortillas are golden and crispy.
Serve warm with sour cream and additional salsa on the side. Garnish with chopped cilantro if desired.